Research References

This page lists significant thyroid studies published in respected medical journals. References will be added to over time.  
An important new article, Time for a reassessment of the treatment of hypothyroidism, by John E. M. Midgley,  with Anthony D. Toft, Rolf Larisch, Johannes W. Dietrich and Rudolf Hoermann was published in BMC Endocrine Disorders, 18th April 2019. 

The following studies were mentioned in Dr Anthony Toft's talk at The Thyroid Trust November 2018 Information Event. 
  1. Jonklaas J, et al 2018 Physician choice of hypothyroidism therapy: influence of patient characteristics. Thyroid 28: 1416-1424.
  2. Peterson AJ, et al 2018 An online survey of hypothyroid patients demonstrates prominent dissatisfaction. Thyroid 28: 707-721.
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The following study references have been provided by Professor Margaret Rayman, one of the speakers at our November 2019 event on nutrition and thyroid disease. Read our interview with Margaret. 
  1. Rayman MP. Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. Proceedings of the Nutrition Society, 2019; 78: 34–44.​
  2. Jo S et al. Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. The Journal of Clinical Investigation, 2019; 129:230-245.  
  3. Hernandez A. Cognitive function in hypothyroidism: what is that deiodinase again? The Journal of Clinical Investigation, 2019; 129:55-57. 
  4. Carlé A et al. Hypothyroid Patients Encoding Combined MCT10 and DIO2 Gene Polymorphisms May Prefer L-T3 + L-T4 Combination Treatment – Data Using a Blind, Randomized, Clinical Study. European Thyroid Journal, 2017; 6:143–151.